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Introduction. Trazodone is a triazolopyridine-derived antidepressant that acts by means of serotonin-2A and -2C (5HT2A/2C) receptor antagonism and through serotonin reuptake inhibition. 1,2 It belongs to a distinct class of antidepressants referred to as serotonin-2 antagonist/reuptake inhibitors (SARIs). Trazodone has moderate histamine-1 (H 1) receptor antagonism and possesses some
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